Anti-HDAC6 Polyclonal Antibody

Name: Anti-HDAC6 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00841
Rating: 4.5 (1 reviews)

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Anti-HDAC6 Polyclonal Antibody is a Rabbit antibody targeting PPARGC1A. Anti-HDAC6 Polyclonal Antibody can be used in WB,IHC-P,IHC-F,IF,ICC/IF.

Anti-HDAC6 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description	Anti-HDAC6 Polyclonal Antibody is a Rabbit antibody targeting PPARGC1A. Anti-HDAC6 Polyclonal Antibody can be used in WB,IHC-P,IHC-F,IF,ICC/IF.
Ig Type	IgG
Reactivity	Human

Application	WB IHC-P IHC-F IF ICC/IF
Recommended Dose	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:50-200
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human HDAC6
Antigen Species	Human
Gene Name	HDAC6
Gene ID	10013
Protein Name	Histone deacetylase 6
Uniprot ID	Q9UBN7
Biology Area	Acetylation,Class II / Hda1 Class,HDACs
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.