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Anti-DSG1 Antibody (4J92)
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Catalog No. TMAC-01189
Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P.
Anti-DSG1 Antibody (4J92)
Anti-DSG1 Antibody (4J92)
😃Good
Catalog No. TMAC-01189
Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat,zebrafish |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200; IHC-P:1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized opeptide: within N-terminal human Aldolase |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Theoretical: 114 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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