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Anti-DSG1 Antibody (4J92)

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Catalog No. TMAC-01189

Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P.

Anti-DSG1 Antibody (4J92)

Anti-DSG1 Antibody (4J92)

😃Good
Catalog No. TMAC-01189
Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4977-10 days
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Product Introduction

Bioactivity
Description
Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P.
Ig Type
IgG
Reactivity
Human,Mouse,Rat,zebrafish
Application
Recommended Dose
WB: 1:500-2000; ICC/IF: 1:50-200; IHC-P:1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundDesmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthesized opeptide: within N-terminal human Aldolase
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 114 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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