TT-OAD2

Name: TT-OAD2
Brand: TargetMol
SKU: T13218
Rating: 4.5 (1 reviews)

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Catalog No. T13218Cas No. 2382719-60-8

TT-OAD2 is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with potential for diabetes treatment.

TT-OAD2

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Catalog No. T13218Cas No. 2382719-60-8

TT-OAD2 is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with potential for diabetes treatment.

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	TT-OAD2 is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with potential for diabetes treatment.
Targets&IC50	GLP1 receptor:(EC50)5 nM
In vitro	In HEK293A cells, TT-OAD2 (0-10 μM) inhibits GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner [1].
In vivo	In male human GLP-1 receptor knock-in and knockout mice, TT-OAD2 (3 mg/kg; intravenous injection)treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1].

Chemical Properties

Molecular Weight	929.75
Formula	C₅₀H₄₉Cl₄N₃O₆
Cas No.	2382719-60-8
Smiles	CC[C@@H](C1=CC=CC=C1)N2[C@@H](CC3=CC(OC[C@@](C4=CC=C(C=C4)OCC5=CC(Cl)=C(C=C5)Cl)([H])O6)=C6C=C3C2)C(N[C@H](C(O)=O)CC7=CC=C(C8=CC=NC(C)=C8C)C=C7)=O.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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