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CGP71683 hydrochloride

Name: CGP71683 hydrochloride
Brand: TargetMol
SKU: T5587
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5587Cas No. 192322-50-2

Alias CGP71683A

CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.

CGP71683 hydrochloride

🥰Excellent

Purity: 99.92%

Catalog No. T5587Alias CGP71683ACas No. 192322-50-2

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$107	In Stock
10 mg	$162	In Stock
25 mg	$269	In Stock
50 mg	$388	In Stock
100 mg	$568	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

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Purity:99.92%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
Targets&IC50	Y5 receptor:1.3 nM (Ki), Y2 receptor:200 nM (Ki), Y1 receptor:>4000 nM (Ki)
In vivo	CGP71683 (1-10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did not have an anxiogenic-like effect in the rat social interaction test. In the open-field test, carried out immediately after the elevated plus-maze test, CGP71683A inhibited horizontal and vertical activity [2].
Synonyms	CGP71683A

Chemical Properties

Molecular Weight	512.07
Formula	C₂₆H₃₀ClN₅O₂S
Cas No.	192322-50-2
Smiles	Cl.Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (234.34 mM), Sonication is recommended.

H2O: 10 mg/mL (19.53 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9529 mL	9.7643 mL	19.5286 mL	97.6429 mL
5 mM	0.3906 mL	1.9529 mL	3.9057 mL	19.5286 mL
10 mM	0.1953 mL	0.9764 mL	1.9529 mL	9.7643 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0976 mL	0.4882 mL	0.9764 mL	4.8821 mL
50 mM	0.0391 mL	0.1953 mL	0.3906 mL	1.9529 mL
100 mM	0.0195 mL	0.0976 mL	0.1953 mL	0.9764 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc