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NPFF1-R antagonist 1
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Catalog No. T209569
NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
NPFF1-R antagonist 1
NPFF1-R antagonist 1
🥰Excellent
Catalog No. T209569
NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
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Product Introduction
Bioactivity
Chemical Properties
| Description | NPFF1-R antagonist 1 (compound 8b) is a piperidine analog and an effective neuropeptide FF (NPFF) receptor antagonist. It exhibits 15-fold selectivity for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively. |
| Targets&IC50 | κ opioid receptor:1390 ± 147 nM (Ki), NPFF1R:211 ± 54 nM (Ki), NPFF2R:3270 ±639 nM (Ki) |
| In vitro | NPFF1-R antagonist 1 (compound 8b) exhibits off-target binding at the opioid receptors (DOR, KOR, and MOR), with K i values of 1540 ± 132, 1390 ± 147, and 3560 ± 364 nM, respectively. At concentrations of 0-10 μM, NPFF1-R antagonist 1 does not inhibit cAMP stimulation but dose-dependently reverses the NPFF-induced inhibition of forskolin-induced cAMP accumulation. |
| Formula | C37H44N4O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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