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Thalidomide-O-amido-PEG3-C2-NH2

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Catalog No. T17915Cas No. 1957236-20-2
Alias E3 Ligase Ligand-Linker Conjugates 14, Cereblon Ligand-Linker Conjugates 3

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate developed using a Thalidomide-based cereblon ligand and a 3-unit PEG linker, synthesized specifically for use in PROTAC technology.

Thalidomide-O-amido-PEG3-C2-NH2
Other Forms of Thalidomide-O-amido-PEG3-C2-NH2:
Thalidomide-O-amido-PEG3-C2-NH2 TFAT77581957236-21-3
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Thalidomide-O-amido-PEG3-C2-NH2

😃Good
Catalog No. T17915Alias E3 Ligase Ligand-Linker Conjugates 14, Cereblon Ligand-Linker Conjugates 3Cas No. 1957236-20-2
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate developed using a Thalidomide-based cereblon ligand and a 3-unit PEG linker, synthesized specifically for use in PROTAC technology.
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Product Introduction

Bioactivity
Description
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate developed using a Thalidomide-based cereblon ligand and a 3-unit PEG linker, synthesized specifically for use in PROTAC technology.
In vitro
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3), comprising a Degron (E3 ubiquitin ligase) and a linker, is employed in PROTAC technology to degrade target proteins like BRD4, BRD2, and BRD3 by binding to the targeting ligand[1].
SynonymsE3 Ligase Ligand-Linker Conjugates 14, Cereblon Ligand-Linker Conjugates 3
Chemical Properties
Molecular Weight506.51
FormulaC23H30N4O9
Cas No.1957236-20-2
Relative Density.1.358 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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