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DL-Dopa
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Catalog No. T15138Cas No. 63-84-3
DL-Dopa is a phenylalanine beta-hydroxylated derivative.
DL-Dopa
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Purity: 98.93%
Catalog No. T15138Cas No. 63-84-3
DL-Dopa is a phenylalanine beta-hydroxylated derivative.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $44 | In Stock | In Stock | |
| 1 g | $64 | In Stock | In Stock | |
| 1 mL x 2.5 mM (in H2O) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.93%
Appearance:Solid
Color:White
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Product Introduction
DL-Dopa AI Summary
DL-Dopa exhibits a diverse range of biological activities and inhibitions. It shows inhibition of the p56lck SH2 domain with an IC50 greater than 500,000 nM and demonstrates a 0.6% inhibition of Jurkat cell activation by blocking T-cell antigen receptor-induced IL-2 expression at 10 µM, as measured by a luciferase assay. The compound has moderate potency as an inhibitor of RecQ-Like Dna Helicase 1 (RECQ1) and also exhibits inhibitory activities against HSD17B4, tyrosyl-DNA phosphodiesterase 1 (TDP1), human Jumonji Domain Containing 2E (JMJD2E), and Apurinic/apyrimidinic Endonuclease 1 (APE1). It is active against various enzymes such as Aldehyde Dehydrogenase 1 (ALDH1A1), 15-hLO, 12-hLO, and HPGD, and is a potential inhibitor against proteins involved in tau fibril formation, the ERK signaling pathway, and the Menin-MLL interaction in MLL related leukemias. The compound displays antiproliferative effects on Plasmodium falciparum strains (3D7, DD2, and HB3) and potential as a Marburg Virus entry inhibitor. It exhibits antioxidant activity through scavenging a range of radicals, including superoxide anion, hydroxyl, alkoxyl, peroxyl, methyl, and singlet oxygen radicals, indicating a strong free radical scavenging capability. Moreover, DL-Dopa has a pKa of 2.21, reflecting its acid-base dissociation properties. It shows SARS-CoV-2 3CL-Pro protease inhibition activity with -17.15% inhibition at 20 µM concentration and exhibits minimal inhibition (-0.13%) of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM concentration after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DL-Dopa is a phenylalanine beta-hydroxylated derivative. |
| Molecular Weight | 197.19 |
| Formula | C9H11NO4 |
| Cas No. | 63-84-3 |
| Smiles | NC(Cc1ccc(O)c(O)c1)C(O)=O |
| Relative Density. | 1.468 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: Insoluble H2O: 2.5 mM, Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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