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Anti-Transglutaminase 2 Antibody (4P75)
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Catalog No. TMAB-13734
Anti-Transglutaminase 2 Antibody (4P75) is a Mouse antibody targeting Transglutaminase 2. Anti-Transglutaminase 2 Antibody (4P75) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-Transglutaminase 2 Antibody (4P75)
Anti-Transglutaminase 2 Antibody (4P75)
😃Good
Catalog No. TMAB-13734
Anti-Transglutaminase 2 Antibody (4P75) is a Mouse antibody targeting Transglutaminase 2. Anti-Transglutaminase 2 Antibody (4P75) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Transglutaminase 2 Antibody (4P75) is a Mouse antibody targeting Transglutaminase 2. Anti-Transglutaminase 2 Antibody (4P75) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Ig Type | IgG1 |
| Clone | 4P75 |
| Reactivity | Human |
| Application | |
| Recommended Dose | ICC/IF=1:50-200; IF=1:200-800; IHC-Fr=1:200-800; IHC-P=1:200-800; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Recombinant Antibody |
| Purification | Affinity Purification |
| Appearance | Liquid |
| Formulation | PBS with 100 μg/ml BSA, 0.15% ProClin300 and 50% glycerol. |
| Research Background | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components. |
| Immunogen | Recombinant Protein: Human TGM2 protein |
| Antigen Species | Human |
| Gene Name | TGM2 |
| Gene ID | |
| Protein Name | Protein-glutamine gamma-glutamyltransferase 2 |
| Uniprot ID | |
| Function | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. |
| Molecular Weight | Theoretical: 78 kDa. Actual: 78 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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