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Granzyme B/GZMB Protein, Human, Recombinant (His)
(Synonyms: SECT, HLP, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CTSGL1, CTLA1, CSP-B, CSPB, CGL-1, CGL1, CCPI) Copy Product InfoSynonyms: SECT, HLP, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CTSGL1, CTLA1, CSP-B, CSPB, CGL-1, CGL1, CCPI
Catalog No. TMPY-00817 Copy Product Info
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $75 | - | In Stock | |
| 10 μg | $118 | - | In Stock | |
| 20 μg | $196 | - | In Stock | |
| 50 μg | $386 | In Stock | In Stock | |
| 100 μg | $660 | 7-10 days | 7-10 days | |
| 200 μg | $1,120 | 7-10 days | 7-10 days | |
| 500 μg | $2,270 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 96%; SEC-HPLC: 98.0%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P10144 |
| Construction | A DNA sequence encoding the proform of human Granzyme B (NP_004122.1) (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Gly 19 |
| Protein Purity | ≥ 97 % as determined by SDS-PAGE ≥ 95 % as determined by SEC-HPLC. https://cdn.targetmol.com/group3/M00/12/EE/CgoaEGZG0zSENzjGAAAAABPielU523.png,https://cdn.targetmol.com/group3/M00/12/EE/CgoaEGZG0zSELABxAAAAAOkP9H4706.png |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | SECT, HLP, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), CTSGL1, CTLA1, CSP-B, CSPB, CGL-1, CGL1, CCPI |
| Research Background |
| Molecular Weight | 27.2 kDa (predicted); 35-40 kDa (reducing condition, due to glycosylation) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: Granzyme B/GZMB Protein, Human, Recombinant (His) chemical structure | Granzyme B/GZMB Protein, Human, Recombinant (His) molecular weight
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