Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM. It effectively degrades BTK in Ramos and JeKo-1 cells with respective DC50 values of 0.5 nM and 0.6 nM. Additionally, PTD10 inhibits cell growth and triggers apoptosis through the activation of both the caspase-dependent and mitochondrial pathways, making it suitable for research on B-cell dysregulation [1].
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Description | PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of 0.5 nM and a KD of 2.28 nM. It effectively degrades BTK in Ramos and JeKo-1 cells with respective DC50 values of 0.5 nM and 0.6 nM. Additionally, PTD10 inhibits cell growth and triggers apoptosis through the activation of both the caspase-dependent and mitochondrial pathways, making it suitable for research on B-cell dysregulation [1]. |
Molecular Weight | 922 |
Formula | C49H51N11O8 |
CAS No. | 2642231-19-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PTD10 2642231-19-2 PROTAC PROTACs inhibitor inhibit