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VAV1 degrader-3
🥰Excellent
Catalog No. T201392Cas No. 3050683-38-7
Alias MRT-6160
VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.
VAV1 degrader-3
🥰Excellent
Purity: 99.66%
Catalog No. T201392Alias MRT-6160Cas No. 3050683-38-7
VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $133 | In Stock | |
| 5 mg | $332 | In Stock | |
| 10 mg | $563 | In Stock | |
| 25 mg | $888 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 200 mg | $2,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $366 | In Stock |
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Purity:99.66%
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Product Introduction
Bioactivity
Chemical Properties
| Description | VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases. |
| In vitro | VAV1 degrader-3 (0-1μM, 24h) induces VAV1 degradation, thereby reducing CD69 expression mediated by the B cell receptor and the secretion of IL-6 and IgG in primary human B cells.
VAV1 degrader-3 inhibits the growth of B lymphoma cells in a concentration-dependent manner. [1] |
| In vivo | VAV1 degrader-3 (1-10 mg/kg, oral) inhibits the progression of experimental autoimmune encephalomyelitis (EAE) in the EAE mouse model in a dose-dependent manner.
In the T cell transfer-induced colitis model, VAV1 degrader-3 (1 mg/kg, oral) inhibited colitis. In the collagen-induced arthritis model, VAV1 degrader-3 (1 mg/kg, 21 days, oral) reduced the production of anti-collagen II IgG1 antibodies and prevented the progression of arthritis. [1] |
| Synonyms | MRT-6160 |
| Molecular Weight | 392.84 |
| Formula | C22H17ClN2O3 |
| Cas No. | 3050683-38-7 |
| Smiles | O=C1C=CC=CN1C2=CC=C(C=C2)C=3C=CC=C(C3Cl)C4C(=O)NC(=O)CC4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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