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VAV1 degrader-3
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Catalog No. T201392Cas No. 3050683-38-7
Alias MRT-6160
VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.
VAV1 degrader-3
😃Good
Purity: 99.66%
Catalog No. T201392Alias MRT-6160Cas No. 3050683-38-7
VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $66 | In Stock | In Stock | |
| 5 mg | $158 | In Stock | In Stock | |
| 10 mg | $228 | In Stock | In Stock | |
| 25 mg | $396 | In Stock | In Stock | |
| 50 mg | $538 | In Stock | In Stock | |
| 100 mg | $795 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $176 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases. |
| In vitro | VAV1 degrader-3 (0-1μM, 24h) induces VAV1 degradation, thereby reducing CD69 expression mediated by the B cell receptor and the secretion of IL-6 and IgG in primary human B cells.
VAV1 degrader-3 inhibits the growth of B lymphoma cells in a concentration-dependent manner. [1] |
| In vivo | VAV1 degrader-3 (1-10 mg/kg, oral) inhibits the progression of experimental autoimmune encephalomyelitis (EAE) in the EAE mouse model in a dose-dependent manner.
In the T cell transfer-induced colitis model, VAV1 degrader-3 (1 mg/kg, oral) inhibited colitis. In the collagen-induced arthritis model, VAV1 degrader-3 (1 mg/kg, 21 days, oral) reduced the production of anti-collagen II IgG1 antibodies and prevented the progression of arthritis. [1] |
| Synonyms | MRT-6160 |
| Molecular Weight | 392.84 |
| Formula | C22H17ClN2O3 |
| Cas No. | 3050683-38-7 |
| Smiles | O=C1C=CC=CN1C2=CC=C(C=C2)C=3C=CC=C(C3Cl)C4C(=O)NC(=O)CC4 |
| Relative Density. | no data available |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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