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VAV1 degrader-3

Name: VAV1 degrader-3
Brand: TargetMol
SKU: T201392
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MRT-6160) Copy Product Info

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Synonyms: MRT-6160

Catalog No. T201392 Copy Product Info

Purity: 99.66%

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VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.

Cas No. 3050683-38-7

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Pack Size	Price	USA Stock	Global Stock
1 mg	$66	In Stock	In Stock
5 mg	$158	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$538	In Stock	In Stock
100 mg	$795	-	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.66%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	VAV1 degrader-3 is an orally active and efficient VAV1 molecular glue degrader that reduces immune cell activation, proliferation, and cytokine production, useful for studying inflammation and autoimmune diseases.
In vitro	VAV1 degrader-3 (0-1μM, 24h) induces VAV1 degradation, thereby reducing CD69 expression mediated by the B cell receptor and the secretion of IL-6 and IgG in primary human B cells. VAV1 degrader-3 inhibits the growth of B lymphoma cells in a concentration-dependent manner. [1]
In vivo	VAV1 degrader-3 (1-10 mg/kg, oral) inhibits the progression of experimental autoimmune encephalomyelitis (EAE) in the EAE mouse model in a dose-dependent manner. In the T cell transfer-induced colitis model, VAV1 degrader-3 (1 mg/kg, oral) inhibited colitis. In the collagen-induced arthritis model, VAV1 degrader-3 (1 mg/kg, 21 days, oral) reduced the production of anti-collagen II IgG1 antibodies and prevented the progression of arthritis. [1]
Synonyms	MRT-6160

Chemical Properties

Molecular Weight	392.84
Formula	C₂₂H₁₇ClN₂O₃
Cas No.	3050683-38-7
Smiles	O=C1C=CC=CN1C2=CC=C(C=C2)C=3C=CC=C(C3Cl)C4C(=O)NC(=O)CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 51.7 mg/mL (131.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 5.17 mg/mL (13.16 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5456 mL	12.7278 mL	25.4557 mL	127.2783 mL
5 mM	0.5091 mL	2.5456 mL	5.0911 mL	25.4557 mL
10 mM	0.2546 mL	1.2728 mL	2.5456 mL	12.7278 mL
20 mM	0.1273 mL	0.6364 mL	1.2728 mL	6.3639 mL
50 mM	0.0509 mL	0.2546 mL	0.5091 mL	2.5456 mL
100 mM	0.0255 mL	0.1273 mL	0.2546 mL	1.2728 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VAV1degrader3

Related Tags: VAV1 degrader-3 chemical structure | VAV1 degrader-3 in vivo | VAV1 degrader-3 in vitro | VAV1 degrader-3 formula | VAV1 degrader-3 molecular weight