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PAR2 (1-6) amide (human) (trifluoroacetate salt)

Catalog No. T35955 CAS 2379569-17-0

Synonyms: PAR2 (1-6) amide (human) (trifluoroacetate salt)

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

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PAR2 (1-6) amide (human) (trifluoroacetate salt) Chemical Structure

PAR2 (1-6) amide (human) (trifluoroacetate salt), CAS 2379569-17-0

Pack Size	Availability	Price/USD
5 mg	35 days	$ 155.00
10 mg	35 days	$ 288.00
25 mg	35 days	$ 598.00
50 mg	35 days	$ 1,120.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PAR2 (1-6) amide (human) (trifluoroacetate salt)
Molecular Weight	728.812
Formula	C30H55F3N8O9
CAS No.	2379569-17-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 5 mg/mL

DMF: 30 mg/mL

DMSO: 15 mg/mL

PBS (pH 7.2): 10 mg/mL

References and Literature

1. Bohm, S.K., Kong, W., Bromme, D., et al.Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2Biochem. J.314(Pt 3)1009-1016(1996) 2. Kanke, T., Ishiwata, H., Kabeya, M., et al.Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2Br. J. Pharmacol.145(2)255-263(2005) 3. Miike, S., McWilliam, A.S., and Kita, H.Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2J. Immunol.167(11)6615-6622(2001) 4. Nishikawa, H., Kawai, K., Tanaka, M., et al.Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: Involvement of PAR-2 and non-PAR-2 mechanismsJ. Pharmacol. Exp. Ther.312(2)324-331(2005)

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Keywords

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