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Amorolfine hydrochloride

Name: Amorolfine hydrochloride
Brand: TargetMol
SKU: T0187
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0187Cas No. 78613-38-4

Alias Ro 14-4767/002, Amorolfine HCl

Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.

Amorolfine hydrochloride

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Purity: 99.94%

Catalog No. T0187Alias Ro 14-4767/002, Amorolfine HClCas No. 78613-38-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$40	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$82	In Stock	In Stock
500 mg	$219	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Amorolfine hydrochloride AI Summary

Amorolfine hydrochloride exhibits significant bioactivity by inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) over a period of 72 hours, though its inhibition index (0.7606) suggests lower efficacy compared to the antiviral control arbidol. Additionally, Amorolfine hydrochloride displays antifungal activity against Candida albicans with a minimum inhibitory concentration (MIC) of 2500.0 nM. However, it shows limited efficacy against Cryptococcus neoformans and a range of bacterial strains (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa PAO397, and Staphylococcus aureus MRSA) with MIC values exceeding 20000.0 nM. The compound's hemolytic concentration (HC10) is greater than 20.0 μM, and it demonstrates low cytotoxicity against HEK293 cells with a CC50 value exceeding 20000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Ro 14-4767/002, Amorolfine HCl

Chemical Properties

Molecular Weight	353.97
Formula	C₂₁H₃₆ClNO
Cas No.	78613-38-4
Smiles	Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
Relative Density.	1.234

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (47.09 mM), Sonication is recommended.

H2O: 9 mg/mL (25.43 mM), Sonication is recommended.

Ethanol: 66 mg/mL (186.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8251 mL	14.1255 mL	28.2510 mL	141.2549 mL
5 mM	0.5650 mL	2.8251 mL	5.6502 mL	28.2510 mL
10 mM	0.2825 mL	1.4125 mL	2.8251 mL	14.1255 mL
20 mM	0.1413 mL	0.7063 mL	1.4125 mL	7.0627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc