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LSD1-IN-36

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Catalog No. T201218

LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.

LSD1-IN-36

LSD1-IN-36

😃Good
Catalog No. T201218
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.
Targets&IC50
LSD1:0.8 nM
In vitro
LSD1-IN-36 (compound 10e) exhibits significant inhibitory effects in various human tumor cell lines, showing strong activity against HCT116, MCF-7, A549, and MDA-MB-231 cells with IC50 values of 0.1 μM, 0.1 μM, 0.3 μM, and 0.8 μM, respectively. At concentrations ranging from 0.125 to 0.5 μM over 72 hours, LSD1-IN-36 significantly inhibits clonal formation in HCT116 cells, induces apoptosis, arrests the cell cycle, and increases the expression of H3K9me2, H3K9me1, H3K4me2, and H3K4me1 in HCT116 cells.
In vivo
Administered intraperitoneally at a dose of 60 mg/kg daily for three weeks, LSD1-IN-36 (compound 10e) demonstrated a significant tumor suppression rate in vivo.
Chemical Properties
Molecular Weight459.52
FormulaC22H25N3O6S
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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