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Telomerase

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of eukaryotic chromosomes in most eukaryotes.

  • Braco-19
    T26892351351-75-2
    Braco-19 is a telomerase/telomere inhibitor and an inhibitor of HAdV viral replication with antiviral activity that reduces lipid vacuolization in adipocytes, inhibits proliferation and decreases telomerase activity in human glioblastoma cells.
    • $48
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  • 360A
    T7409794458-56-3
    360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
    • $97
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    TargetMol | Citations Cited
  • Telomerase-IN-1
    T12009666859-49-0In house
    Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apoptosis. telomerase-IN-1 leads to inhibition of cell proliferation through the expression of downstream signaling molecules including Telomease-IN-1 has high inhibitory activity against telomerase, high anti-proliferative capacity against SMMC-7721 cells, and no significant toxic effect on human normal hepatocytes. telomerase-IN-1 in xenograft tumor model exhibited antitumor activity.
    • $82
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  • L-778123 hydrochloride
    T3182253863-00-2
    The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
    • $38
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    TargetMol | Citations Cited
  • RHPS4
    T6967390362-78-4
    RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.
    • $39
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    TargetMol | Citations Cited
  • Zidovudine
    T141630516-87-1
    Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
    • $44
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    TargetMol | Citations Cited
  • 7-Deaza-2′-deoxyguanosine 5′-triphosphate
    T83248101515-08-6
    7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].
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  • Lipiferolide
    TN444341059-80-7
    Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.
    • $520
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  • BMVC
    T10574627810-06-4
    BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).
    • $916
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  • Ceramides Mixture
    T10760100403-19-8
    Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.
    • $32
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  • MST-312
    T41290368449-04-1
    MST-312 (Telomerase Inhibitor IX) is a derivative of green tea epigallocatechin gallate (EGCG). MST-312 is a telomerase inhibitor. MST-312 has research value in cancer, such as multiple myeloma (MM).
    • $30
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  • TMPyP4 tosylate
    T1317436951-72-1
    TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
    • $32
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  • Telomerase-IN-2
    T131151610878-54-0
    Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).
    • $135
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    TargetMol | Inhibitor Sale
  • Costunolide
    T2902553-21-9
    Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.
    • $55
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  • Braco-19 trihydrochloride
    T238191177798-88-7
    Braco-19 trihydrochloride (BRACO19 3HCl) is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. Braco-19 trihydrochloride inhibits HAdV virus replication.
    • $48
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  • Cyclogalegenin
    T333384605-18-5
    Cyclogalegenin (Astramembrangenin) is able to elongate telomeres, resulting in increased lifespan of the animals.
    • $39
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  • BIBR 1532
    T2380321674-73-1
    BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).
    • $45
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  • 360A iodide
    T13504737763-37-0
    360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).
    • $747
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  • Cycloastragenol
    T557578574-94-4
    Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression
    • $39
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  • Adefovir
    T7447106941-25-7
    Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
    • $41
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