Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 332.00 | |
50 mg | Inquiry | $ 1,820.00 | |
100 mg | Inquiry | $ 2,500.00 |
Description | BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution. |
Synonyms | NKP-1339 free base ; IT-139 free base ; KP-1339 free base, KP-1339 free base, NKP-1339 free base, IT-139 free base |
Molecular Weight | 479.15 |
Formula | C14H12Cl4N4Ru |
CAS No. | 783324-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BOLD-100 free base 783324-98-1 BOLD-100 NKP-1339 free base ; IT-139 free base ; KP-1339 free base KP1339 IT-139 NKP-1339 free base ; IT-139 free base ; KP-1339 IT139 KP-1339 free base NKP-1339 free base ; IT-139 free base ; KP1339 NKP-1339 free base NKP-1339 free base ; IT-139 free base ; KP 1339 KP-1339 BOLD100 NKP-1339 IT-139 free base IT 139 BOLD 100 KP 1339 NKP1339 NKP 1339 inhibitor inhibit