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PI3K/Akt/mTOR signalingPTEN
Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available. PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. It is a target of many anticancer drugs.
FCCP
Cited
T6834370-86-5
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
- $34
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CitedCucurbitacin B Cited
T34046199-67-3
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
- $44
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CitedCCCP Cited
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
- $41
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CitedSalidroside
T271710338-51-9
Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor. Salidroside can alleviate cachexia symptoms in a tumor cachexia mouse model by activating mTOR signaling and protect dopaminergic neurons by enhancing PINK1 Parkin-mediated mitochondrial autophagy. Salidroside can also inhibit the growth of cancer cells by regulating the CDK4-cyclin D1 pathway to block the G1 phase and or regulating the Cdc2-cyclin B1 pathway to block the G2 phase.
- $30
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Valinomycin Cited
TP10722001-95-8
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
- $40
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CitedMatrine
T2870519-02-8
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
- $36
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Afzelin
TN1362482-39-3
Afzelin (Kaempferol-3-O-rhamnoside) exhibits several cellular activities such as DNA-protective, antibacterial, antioxidant, anti-inflammatory, and UV-absorbing properties, potentially protecting human skin from UVB-induced damage through a combination of UV-absorbing and cellular actions. Afzelin mitigates mitochondrial damage, promotes mitochondrial biogenesis, and reduces levels of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.
- $41
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MTK458
T724202499962-58-0
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1 TOM complex.MTK458 may be used in Parkinson's disease research.
- $32
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BpV(HOpic)
T7953722494-26-0
BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).
- $39
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VO-Ohpic trihydrate Cited
T7012476310-60-8
VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.
- $52
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CitedGinkgolic acid C17:1
T6S2116111047-30-4
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
- $92
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SF1670 Cited
T6667345630-40-2
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
- $37
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CitedSQLE-IN-1
T836581019169-83-5
SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the expression of the tumor suppressor gene PTEN. expression, inhibiting the protein expression of PI3K and AKT.
- $93
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MitoBloCK-11 (MB-11)
T8782413606-16-3
MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20; inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development.
- $45
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CIB-L43
T2056071082942-70-8
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
- $64
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Kinetin triphosphate tetrasodium
T203014
Kinetin triphosphate tetrasodium (KTP tetrasodium) is the tetrasodium salt form of Kinetin triphosphate, an ATP analog that enhances the activity of Parkinson's disease-associated mutant mitochondrial kinases PINK1(G309D) and PINK1(WT) and has therapeutic potential for neurodegenerative diseases.
- $249
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bpV(phen)
T1059442494-73-5
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
- $1,520
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bpV(pic) (potassium hydrate)
T35630148556-27-8
bpV(pic) (potassium hydrate) can be used in related research in the field of life sciences. Its product number is T35630 and CAS number is 148556-27-8.
- $195
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FT3967385
T61512
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through the PINK1-PARKIN pathway.
- $1,520
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Penisterpenoid A
T89420
Penisterpenoid A (Compound 1), an activator of the PINK1 Parkin mitochondrial autophagy signaling pathway, is derived from the rhizosphere fungi of the medicinal plant Bupleurum. In both in vitro and in vivo settings, Penisterpenoid A effectively reduces lipid accumulation and significantly enhances mitochondrial function.
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Autophagy agonist-1
T205669
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1 S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.
- Inquiry Price
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Coelonin
TN368882344-82-9
Coelonin shows moderate cytotoxic activity against HepG2 cells.
- $1,530
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VO-OHPic
T61344675848-25-6
VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM, effectively attenuating apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].
- $696
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