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Anti-NPC1L1 Antibody (7Y606)
😃Good
Catalog No. TMAH-00821
Anti-NPC1L1 Antibody (7Y606) is an antibody targeting NPC1L1. Anti-NPC1L1 Antibody (7Y606) can be used in ELISA,IHC.
Anti-NPC1L1 Antibody (7Y606)
Anti-NPC1L1 Antibody (7Y606)
😃Good
Catalog No. TMAH-00821
Anti-NPC1L1 Antibody (7Y606) is an antibody targeting NPC1L1. Anti-NPC1L1 Antibody (7Y606) can be used in ELISA,IHC.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-NPC1L1 Antibody (7Y606) is an antibody targeting NPC1L1. Anti-NPC1L1 Antibody (7Y606) can be used in ELISA,IHC. |
| Ig Type | Rabbit IgG |
| Clone | 7Y606 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00821 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human NPC1L1 |
| Antigen Species | Human |
| Gene Name | NPC1L1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Cardiovascular, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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