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VU0155041 sodium (Synonyms: VU 0155041 sodium salt)

Name: VU0155041 sodium
Brand: TargetMol
SKU: T23507
Rating: 4.5 (1 reviews)

Catalog No. T23507 Copy Product Info

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VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.

VU0155041 sodium

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Catalog No. T23507

Synonyms VU 0155041 sodium salt

Cas No. 1259372-69-4

Pack Size	Price	USA Stock	Global Stock
5 mg	$108	35 days	35 days
10 mg	$198	35 days	35 days
50 mg	$568	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
Targets&IC50	mGluR4:693 nM (EC50)
In vitro	VU0155041 sodium (10 μM) did not affect NMDA receptor currents in medium spiny neurons in the striatum, indicating that it does not antagonize NMDA receptor activity.[1]
Synonyms	VU 0155041 sodium salt

Chemical Properties

Molecular Weight	338.16
Formula	C₁₄H₁₄Cl₂NNaO₃
Cas No.	1259372-69-4
Smiles	ClC1=CC(Cl)=CC(NC([C@H]2[C@H](CCCC2)C([O-])=O)=O)=C1.[Na+]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8 mg/mL (23.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.9572 mL	14.7859 mL	29.5718 mL	147.8590 mL
5 mM	0.5914 mL	2.9572 mL	5.9144 mL	29.5718 mL
10 mM	0.2957 mL	1.4786 mL	2.9572 mL	14.7859 mL
20 mM	0.1479 mL	0.7393 mL	1.4786 mL	7.3930 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc