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VU0155041 sodium

Name: VU0155041 sodium
Brand: TargetMol
SKU: T23507
Rating: 4.5 (1 reviews)

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Catalog No. T23507Cas No. 1259372-69-4

Alias VU 0155041 sodium salt

VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.

VU0155041 sodium

😃Good

Catalog No. T23507Alias VU 0155041 sodium saltCas No. 1259372-69-4

Pack Size	Price	Availability
5 mg	$108	35 days
10 mg	$198	35 days
50 mg	$568	35 days

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Product Introduction

Bioactivity

Description	VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
Targets&IC50	mGluR4:693 nM (EC50)
In vitro	VU0155041 sodium (10 μM) did not affect NMDA receptor currents in medium spiny neurons in the striatum, indicating that it does not antagonize NMDA receptor activity.[1]
Synonyms	VU 0155041 sodium salt

Chemical Properties

Molecular Weight	338.16
Formula	C₁₄H₁₄Cl₂NNaO₃
Cas No.	1259372-69-4
Smiles	ClC1=CC(Cl)=CC(NC([C@H]2[C@H](CCCC2)C([O-])=O)=O)=C1.[Na+]
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8.00 mg/mL (23.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.9572 mL	14.7859 mL	29.5718 mL	147.8590 mL
5 mM	0.5914 mL	2.9572 mL	5.9144 mL	29.5718 mL
10 mM	0.2957 mL	1.4786 mL	2.9572 mL	14.7859 mL
20 mM	0.1479 mL	0.7393 mL	1.4786 mL	7.3930 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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