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FRAX1036
🥰Excellent
Catalog No. T6839Cas No. 1432908-05-8
FRAX-1036 is a effective and selective PAK1 inhibitor.
FRAX1036
🥰Excellent
Purity: 98.67%
Catalog No. T6839Cas No. 1432908-05-8
FRAX-1036 is a effective and selective PAK1 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $47 | In Stock | |
| 2 mg | $63 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $122 | In Stock | |
| 25 mg | $222 | In Stock | |
| 50 mg | $372 | In Stock | |
| 100 mg | $538 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:98.67%
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Product Introduction
Bioactivity
Chemical Properties
| Description | FRAX-1036 is a effective and selective PAK1 inhibitor. |
| Targets&IC50 | PAK1:23.3 nM(Ki), PAK2:72.4 nM(Ki), PAK4:2.4 μM(Ki) |
| In vitro | MDA-MB-175 cells,which are PAK1-amplified (MEK1-S298 and CRAF-S338) ,was observed Potent cellular inhibition at 2.5 to 5 μM concentrations of FRAX1036. PAK1-amplified breast cancer cells are treated with FRAX1036 leading to apoptosis. OVCAR-3 cells are treated with FRAX-1036 resulting in upregulation of p53 and p21, while down-regulating cyclin B1. |
| In vivo | KT21 are treated with Frax1036 showing slower tumor growth, while Frax1036 is unlikely to have significant blood-brain barrier permeability in mice. |
| Cell Research | MDA-MB175 cells are treated with increasing concentrations (0, 0.5, 1, 2.5, 5 μM) of FRAX1036 for 24 hours. |
| Animal Research | Pak2-deficient mice were treated by oral gavage of 30 mg/kg Frax1036. |
| Molecular Weight | 518.05 |
| Formula | C28H32ClN7O |
| Cas No. | 1432908-05-8 |
| Smiles | CCn1c2nc(NCCC3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncc(C)n2)c1=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: insoluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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