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IL-17A Protein, Cynomolgus, Recombinant (His)

Catalog No. TMPJ-01444
Synonyms: CTLA-8, CTLA8, IL17A, IL-17, IL-17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, Interleukin-17A, IL17

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
IL-17A Protein, Cynomolgus, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 123.00
50 μg 5 days $ 371.00
500 μg 5 days $ 2,110.00
1 mg 5 days $ 3,160.00
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Biological Description
Technical Params
Product Properties
Description Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
Species Cynomolgus
Expression System Human Cells
Tag C-6His
Accession Number G7P4U9
Synonyms CTLA-8, CTLA8, IL17A, IL-17, IL-17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, Interleukin-17A, IL17
Amino Acid Gly24­Ala155
Construction Recombinant Cynomolgus Interleukin-17A is produced by our Mammalian expression system and the target gene encoding Gly24­Ala155 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 15-25 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

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Keywords

IL-17A Protein, Cynomolgus, Recombinant (His) CTLA-8 CTLA8 IL 17 IL17A IL-17 IL-17A CTLA 8 Cytotoxic T-Lymphocyte-Associated Antigen 8 Interleukin-17A IL17 recombinant recombinant-proteins proteins protein

 

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