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Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) (Synonyms: CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsil...)

Catalog No. TMAY-01395F Copy Product Info
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Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) is a FITC-conjugated Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) can be used in FCM.

Anti-CD3 epsilon/CD3e Antibody-FITC (6O384)

Copy Product Info
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Catalog No. TMAY-01395F
Synonyms CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) is a FITC-conjugated Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) can be used in FCM.

Anti-CD3 epsilon/CD3e Antibody-FITC
(6O384)
Pack SizePriceUSA StockGlobal StockQuantity
25 T$167-10 days7-10 days
100 T$827-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) is a FITC-conjugated Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody-FITC (6O384) can be used in FCM.
SynonymsCD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e
Ig Type
Mouse IgG2a
Clone
6O384
Reactivity
Human
Specificity
Human CD3 epsilon/CD3e
Verified Activity
Flow cytometric analysis of Human CD3 expression on human peripheral blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD3 and APC conjugated anti-Human CD19 (BD Pharmingen™ Cat. No. 555415). The dot plots were derived from events with the forward and side light-scatter characteristics of viable lymphocytes.
Application
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis product is a recombinant monoclonal antibody expressed from HEK293 cells and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundT-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
FITC
Others Formats
Unconjugated/APC/PerCP/PE
Antibody Types Available
5
Antigen Details
Immunogen
Recombinant Protein: Human CD3e / CD3 epsilon protein (TMPY-01191)
Antigen Species
Human
Biology Area
ITIM/ITAM Immunoreceptors and Related Molecules
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

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