KR-27370

Name: KR-27370
Brand: TargetMol
SKU: T209484
Rating: 4.5 (1 reviews)

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Catalog No. T209484

KR-27370 (compound 7f) is an antiviral agent and a selective PI4KIIIβ/PI4KIIIα inhibitor, with IC50 values of 3.1 nM and 15.8 nM, respectively. It exhibits inhibitory activity against human rhinovirus (hRV), Coxsackievirus, and other enteroviruses.

KR-27370

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Catalog No. T209484

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Product Introduction

Bioactivity

Description	KR-27370 (compound 7f) is an antiviral agent and a selective PI4KIIIβ/PI4KIIIα inhibitor, with IC50 values of 3.1 nM and 15.8 nM, respectively. It exhibits inhibitory activity against human rhinovirus (hRV), Coxsackievirus, and other enteroviruses.
Targets&IC50	PI4KIIIβ:3.1 nM, PI4KIIIα:15.8 nM
In vitro	KR-27370 exhibits low cytotoxicity (CC50: >100 μM, H1HeLa) and demonstrates effective antiviral activity against hRV B14, hRV A16, and hRV A21 with EC50 values of 22 nM, 32 nM, and 36 nM, respectively.

Chemical Properties

Formula

C₂₇H₂₇N₃O₆S₂

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc