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Fedovapagon

Name: Fedovapagon
Brand: TargetMol
SKU: T15273
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15273Cas No. 347887-36-9

Alias VA483, A106483

Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. It can be used to study overactive bladder, nocturia, and painful bladder syndromes.

Fedovapagon

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Purity: 99.46%

Catalog No. T15273Alias VA483, A106483Cas No. 347887-36-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$113	-	In Stock
10 mg	$179	-	In Stock
25 mg	$392	-	In Stock
50 mg	$689	-	In Stock
100 mg	$973	-	In Stock
1 mL x 10 mM (in DMSO)	$126	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.46%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. It can be used to study overactive bladder, nocturia, and painful bladder syndromes.
Targets&IC50	V2 receptor:24 nM (EC50)
In vivo	In rats, oral administration of fedovapagon at a dose of 1 mg/kg results in an 81% inhibition rate of urine output[1].
Synonyms	VA483, A106483

Chemical Properties

Molecular Weight	462.58
Formula	C₂₇H₃₄N₄O₃
Cas No.	347887-36-9
Smiles	[H][C@]1(CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1CCCCc2ccccc12)C(=O)N(C)C
Relative Density.	1.203 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (108.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1618 mL	10.8089 mL	21.6179 mL	108.0894 mL
5 mM	0.4324 mL	2.1618 mL	4.3236 mL	21.6179 mL
10 mM	0.2162 mL	1.0809 mL	2.1618 mL	10.8089 mL
20 mM	0.1081 mL	0.5404 mL	1.0809 mL	5.4045 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1618 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc