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Anti-Phospho-PKM (Ser37) Polyclonal Antibody
(Synonyms: THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP) Copy Product Info
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Synonyms: THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP
Catalog No. TMAC-03352 Copy Product Info
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Anti-Phospho-PKM (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKM (Ser37). Anti-Phospho-PKM (Ser37) Polyclonal Antibody can be used in IF,WB.
Anti-Phospho-PKM
(Ser37) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 µL | $218 | 7-10 days | 7-10 days | |
| 100 µL | $318 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-Phospho-PKM (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKM (Ser37). Anti-Phospho-PKM (Ser37) Polyclonal Antibody can be used in IF,WB. |
| Synonyms | THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of in vitro kinase assays carried out with puried active ERK2, wild-type (WT) PKM2 and PKM2 S37A mutant using PKM2 (phospho-Ser37)Antibody TMAC-03352. 2. Immunofluorescence staining of methanol-fixed MEF cells using PKM2 (phospho-Ser37) Antibody TMAC-03352.  , |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Weiwei Yang1, Yanhua Zheng1, Yan Xia1, Haitao Ji, "ERK1/2-dependent phosphorylation and nucleartranslocation of PKM2 promotes the Warburg effect." Nature Cell Biology(2012)|doi:10.1038/ncb2629 |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2 |
| Antigen Species | Human |
| Uniprot ID |
| Molecular Weight | Actual: 60 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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