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Anti-DR4/TRAIL R1 Antibody (3R561) (Synonyms: tumor necrosis factor receptor superfamily member 10a, TRAILR-1||...)

Name: Anti-DR4/TRAIL R1 Antibody (3R561)
Brand: TargetMol
SKU: TMAY-00781
Rating: 4.5 (1 reviews)

Catalog No. TMAY-00781 Copy Product Info

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Anti-DR4/TRAIL R1 Antibody (3R561) is a Rabbit antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (3R561) can be used in FCM.

Anti-DR4/TRAIL R1 Antibody (3R561)

Copy Product Info

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Catalog No. TMAY-00781

Synonyms tumor necrosis factor receptor superfamily member 10a, TRAILR-1, TRAILR1, TNFRSF10A, MGC9365, DR4, CD261, APO2

Anti-DR4/TRAIL R1 Antibody (3R561) is a Rabbit antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (3R561) can be used in FCM.

Anti-DR4/TRAIL R1 Antibody
(3R561)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$269	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-DR4/TRAIL R1 Antibody (3R561) is a Rabbit antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (3R561) can be used in FCM.
Synonyms	tumor necrosis factor receptor superfamily member 10a, TRAILR-1, TRAILR1, TNFRSF10A, MGC9365, DR4, CD261, APO2
Ig Type	Rabbit IgG
Clone	3R561
Reactivity	Human
Specificity	Human DR4/TRAIL R1
Verified Activity	Flow cytometric analysis of Human TNFRSF10A(CD261) on HeLa cells. Cells were stained with purified anti-Human TNFRSF10A(CD261) (Filled hisgram), then stained with a FITC-conjugated second step antibody. To demonstrate specificity of staining, the binding by Anti-DR4/TRAIL R1 Antibody was blocked by preincubation of the purified antibody with 20ug recombinant human TNFRSF10A(CD261) for 1 hour (Black solid line hisgram).
Application	FCM
Recommended Dose	FCM: 1:25-1:100
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; TMPY-01720; NP_003835.2; Met1-Asn239).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human TRAIL R1 / CD261 / TNFRSF10A Protein (TMPY-01720)
Antigen Species	Human
Biology Area	Cancer Drug Targets

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

TRAILR 1MGC-9365MGC 9365DR-4DR 4CD-261CD 261APO-2APO 2

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