I-309 Protein, Human, Recombinant

I-309 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.7 kDa and the accession number is P22362.

Pack Size	Availability	Price/USD
20 μg	5 days	$ 212.00
100 μg	5 days	$ 539.00
1 mg	5 days	$ 3,520.00

Pack Size

Availability

Price/USD

Quantity

20 μg

5 days

$ 212.00

100 μg

5 days

$ 539.00

1 mg

5 days

$ 3,520.00

Description

I-309 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.7 kDa and the accession number is P22362.

Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P22362
Synonyms	SISe, P500, TCA3, I-309, chemokine (C-C motif) ligand 1, SCYA1
Construction	The Human CCL1 (P22362) (Lys24-Lys96) was expressed, with a N-terminal Met.
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	8.7 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 40% acetonitrile, 0.1% TFA, 20% H2O. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induces significant levels of LTC4 from elicited eosinophils.