I-309/CCL1 Protein, Human, Recombinant

Name: I-309/CCL1 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-03071
Rating: 4.5 (1 reviews)

(Synonyms: TCA3, SISe, SCYA1, P500, I-309, chemokine (C-C motif) ligand 1) Copy Product Info

Synonyms: TCA3, SISe, SCYA1, P500, I-309, chemokine (C-C motif) ligand 1

Catalog No. TMPY-03071 Copy Product Info

I-309 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.7 kDa and the accession number is P22362.

Pack Size	Price	USA Stock	Global Stock
5 µg	$174	7-10 days	7-10 days
10 µg	$242	7-10 days	7-10 days
20 µg	$348	7-10 days	7-10 days
50 µg	$682	7-10 days	7-10 days
100 µg	$1,060	7-10 days	7-10 days
200 µg	$1,590	7-10 days	7-10 days
500 µg	$3,180	7-10 days	7-10 days
1 mg	$4,770	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	I-309 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.7 kDa and the accession number is P22362.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P22362
Construction	A DNA sequence encoding the human CCL1 (P22362) (Lys24-Lys96) was expressed, with a N-terminal Met. Predicted N terminal: Met
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 40% acetonitrile, 0.1% TFA, 20% H2O. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TCA3, SISe, SCYA1, P500, I-309, chemokine (C-C motif) ligand 1
Research Background	CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induces significant levels of LTC4 from elicited eosinophils.

Chemical Properties

Molecular Weight

8.7 kDa (predicted); 9 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.