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(20S)-Protopanaxatriol

Name: (20S)-Protopanaxatriol
Brand: TargetMol
SKU: T2810
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2810Cas No. 34080-08-5

Alias g-PPT, 20(S)-APPT

(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.

(20S)-Protopanaxatriol

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Purity: 99%

Catalog No. T2810Alias g-PPT, 20(S)-APPTCas No. 34080-08-5

(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	In Stock	In Stock
200 mg	$492	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99%

Appearance:Solid

Color:White

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Product Introduction

(20S)-Protopanaxatriol AI Summary

(20S)-Protopanaxatriol exhibits multiple bioactivities across various cell types and assays. It shows significant antiproliferative effects on HUVEC cells with an EC50 of 6.64 µg/mL after 72 hours and reduces cell viability to 16.5% at 20 µg/mL. The compound also demonstrates cytotoxicity against several human cancer cell lines, including BGC823 cells with an IC50 of 16,000 nM after 48 hours, MDA-MB-231 cells with an IC50 of 12,200 nM after 4 hours, HL60 cells with an IC50 of 22,790 nM after 48 hours, and HepG2 cells with an IC50 of 43,440 nM after 48 hours. Additionally, (20S)-Protopanaxatriol confers renoprotective activity against oxidative damage in pig LLC-PK1 cells, maintaining cell viability at varying concentrations (85.7% at 10 µg/mL, 73.3% at 5 µg/mL, and 61.1% at 1 µg/mL). In antiviral assays, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a minimal inhibition rate of 0.33% at 10 µM and shows inhibition of SARS-CoV-2 3CL-Pro protease with an inhibition percentage of -3.726% at 20 µM as observed through a FRET-based assay. It also affects SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Moreover, (20S)-Protopanaxatriol activates human CK-MM enzyme activity in a dose-dependent manner, with the highest increase at 20 µM, while showing a lesser effect on rabbit CK-MM enzyme activity. Inhibition studies reveal its potential to inhibit HDAC6 enzyme activity, with inhibitory effects recorded as -24.81% using a commercial substrate and -3.01% with a custom peptide substrate. Overall, (20S)-Protopanaxatriol presents a broad spectrum of biological activities, including antiproliferative, cytotoxic, renoprotective, antiviral, enzyme activation, and enzyme inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
Synonyms	g-PPT, 20(S)-APPT

Chemical Properties

Molecular Weight	476.73
Formula	C₃₀H₅₂O₄
Cas No.	34080-08-5
Smiles	CC(C)=CCC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3[C@@H](O)C[C@@]21C
Relative Density.	1.079 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (94.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0976 mL	10.4881 mL	20.9762 mL	104.8812 mL
5 mM	0.4195 mL	2.0976 mL	4.1952 mL	20.9762 mL
10 mM	0.2098 mL	1.0488 mL	2.0976 mL	10.4881 mL
20 mM	0.1049 mL	0.5244 mL	1.0488 mL	5.2441 mL
50 mM	0.0420 mL	0.2098 mL	0.4195 mL	2.0976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc