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Arimoclomol

Name: Arimoclomol
Brand: TargetMol
SKU: T13553
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13553Cas No. 289893-25-0

Alias BRX-220 free base

Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).

Arimoclomol

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Purity: 99.15%

Catalog No. T13553Alias BRX-220 free baseCas No. 289893-25-0

Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$219	In Stock	In Stock
100 mg	$326	-	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).
In vivo	In male Wistar rats, Arimoclomol (20 mg/kg; gavage) protects cholecystokinin-octapeptide (CCK)-induced acute pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased[2].
Synonyms	BRX-220 free base

Chemical Properties

Molecular Weight	313.78
Formula	C₁₄H₂₀ClN₃O₃
Cas No.	289893-25-0
Smiles	C(=NOC[C@@H](CN1CCCCC1)O)(Cl)C2=CN(=O)=CC=C2
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (478.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1869 mL	15.9347 mL	31.8695 mL	159.3473 mL
5 mM	0.6374 mL	3.1869 mL	6.3739 mL	31.8695 mL
10 mM	0.3187 mL	1.5935 mL	3.1869 mL	15.9347 mL
20 mM	0.1593 mL	0.7967 mL	1.5935 mL	7.9674 mL
50 mM	0.0637 mL	0.3187 mL	0.6374 mL	3.1869 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc