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Arimoclomol

Name: Arimoclomol
Brand: TargetMol
SKU: T13553
Price: 92 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13553Cas No. 289893-25-0

Alias BRX-220 free base

Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).

Arimoclomol

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Purity: 99.15%

Catalog No. T13553Alias BRX-220 free baseCas No. 289893-25-0

Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).

Pack Size	Price	Availability
1 mg	$92	In Stock
5 mg	$226	In Stock
10 mg	$347	In Stock
25 mg	$577	In Stock
50 mg	$823	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock

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Batch Information

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Purity:99.15%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Arimoclomol (BRX-220 free base), a co-inducer of heat shock proteins (HSP), is utilized in studies on the treatment of amyotrophic lateral sclerosis (ALS).
In vivo	In male Wistar rats, Arimoclomol (20 mg/kg; gavage) protects cholecystokinin-octapeptide (CCK)-induced acute pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased[2].
Synonyms	BRX-220 free base

Chemical Properties

Molecular Weight	313.78
Formula	C₁₄H₂₀ClN₃O₃
Cas No.	289893-25-0
Smiles	C(=NOC[C@@H](CN1CCCCC1)O)(Cl)C2=CN(=O)=CC=C2
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (207.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1869 mL	15.9347 mL	31.8695 mL	159.3473 mL
5 mM	0.6374 mL	3.1869 mL	6.3739 mL	31.8695 mL
10 mM	0.3187 mL	1.5935 mL	3.1869 mL	15.9347 mL
20 mM	0.1593 mL	0.7967 mL	1.5935 mL	7.9674 mL
50 mM	0.0637 mL	0.3187 mL	0.6374 mL	3.1869 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5935 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc