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Biperiden Hydrochloride

Name: Biperiden Hydrochloride
Brand: TargetMol
SKU: T14614
Rating: 4.5 (1 reviews)

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Catalog No. T14614Cas No. 1235-82-1

Alias KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 Hydrochloride

Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.

Biperiden Hydrochloride

😃Good

Catalog No. T14614Alias KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 HydrochlorideCas No. 1235-82-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$558	35 days	35 days
50 mg	$2,370	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.
In vitro	In human pancreatic ductal adenocarcinoma cell lines (Panc-1, Panc-2, and BxPC3), treatment with Biperiden Hydrochloride (29.6 μg/mL) for 72 hours inhibited cell proliferation and induced apoptosis [1].
In vivo	In a subcutaneous xenograft mouse model using Panc-1 pancreatic cancer cells, intraperitoneal administration of Biperiden Hydrochloride (10 mg/kg, Daily) for 3 weeks resulted in an 83% reduction in tumor size via MALT1 inhibition [4]. Separately, in a pilocarpine-induced epilepsy model, Biperiden treatment (8 mg/kg, i.p., every 8 hours) for 10 days modified the progression of epileptogenesis. It reduced the frequency of spontaneous recurrent seizures and lowered extracellular glutamate levels in the hippocampus, leading to a long-term decrease in hippocampal excitability [5].
Synonyms	KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 Hydrochloride

Chemical Properties

Molecular Weight	347.92
Formula	C₂₁H₃₀ClNO
Cas No.	1235-82-1
Smiles	Cl.OC(C=1C=CC=CC1)(CCN2CCCCC2)C3CC4C=CC3C4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.6 mg/mL (7.47 mM), Sonication is recommended.

H2O: 5 mg/mL (14.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8742 mL	14.3711 mL	28.7422 mL	143.7112 mL
5 mM	0.5748 mL	2.8742 mL	5.7484 mL	28.7422 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.2874 mL	1.4371 mL	2.8742 mL	14.3711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc