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Biperiden Hydrochloride

Name: Biperiden Hydrochloride
Brand: TargetMol
SKU: T14614
Rating: 4.5 (1 reviews)

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Catalog No. T14614Cas No. 1235-82-1

Alias KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 Hydrochloride

Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.

Biperiden Hydrochloride

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Catalog No. T14614Alias KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 HydrochlorideCas No. 1235-82-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$558	35 days	35 days
50 mg	$2,370	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Biperiden Hydrochloride (KL 373 Hydrochloride) is an anticholinergic antiparkinsonian agent that selectively blocks central M1 cholinoreceptors while exerting atropine-like effects on peripheral parasympathetic structures. Biperiden Hydrochloride is approved for the adjunctive treatment of postencephalitic, idiopathic, and arteriosclerotic Parkinson’s disease, demonstrates minimal impairment of novelty preference compared with other anticholinergics in comparative cognitive studies, and is associated with known adverse effects including drowsiness, vertigo, headache, and dizziness.
In vitro	In human pancreatic ductal adenocarcinoma cell lines (Panc-1, Panc-2, and BxPC3), treatment with Biperiden Hydrochloride (29.6 μg/mL) for 72 hours inhibited cell proliferation and induced apoptosis [1].
In vivo	In a subcutaneous xenograft mouse model using Panc-1 pancreatic cancer cells, intraperitoneal administration of Biperiden Hydrochloride (10 mg/kg, Daily) for 3 weeks resulted in an 83% reduction in tumor size via MALT1 inhibition [4]. Separately, in a pilocarpine-induced epilepsy model, Biperiden treatment (8 mg/kg, i.p., every 8 hours) for 10 days modified the progression of epileptogenesis. It reduced the frequency of spontaneous recurrent seizures and lowered extracellular glutamate levels in the hippocampus, leading to a long-term decrease in hippocampal excitability [5].
Synonyms	KL-373 Hydrochloride, KL373 Hydrochloride, KL 373 Hydrochloride

Chemical Properties

Molecular Weight	347.92
Formula	C₂₁H₃₀ClNO
Cas No.	1235-82-1
Smiles	Cl.OC(C=1C=CC=CC1)(CCN2CCCCC2)C3CC4C=CC3C4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.6 mg/mL (7.47 mM), Sonication is recommended.

H2O: 5 mg/mL (14.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8742 mL	14.3711 mL	28.7422 mL	143.7112 mL
5 mM	0.5748 mL	2.8742 mL	5.7484 mL	28.7422 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.2874 mL	1.4371 mL	2.8742 mL	14.3711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc