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Anti-NRG1 Beta 1 Antibody (1T318) is a Mouse antibody targeting NRG1 Beta 1. Anti-NRG1 Beta 1 Antibody (1T318) can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $199 | 7-10 days |
Description | Anti-NRG1 Beta 1 Antibody (1T318) is a Mouse antibody targeting NRG1 Beta 1. Anti-NRG1 Beta 1 Antibody (1T318) can be used in WB. |
Alias | SMDF, NRG1-IT2, NRG1 β1, Neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA |
Ig Type | Monoclonal Mouse IgG2b |
Clone | 1T318 |
Reactivity | Human |
Verified Activity | Anti-NRG1-beta 1 mouse monoclonal antibody at 1:500Lane A: Human NRG1-beta1 (100ng) -Lane B: Human NRG1-alpha (100ng) -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Performed under reducing conditions. |
Application | WB |
Recommended Dose | WB: 1:500-1:2000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
Conjucates | Unconjugated |
Others Formats | APC/FITC/PE |
Antibody Types Available | 4 |
Immunogen | A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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