NRG1 beta 1 Protein, Human, Recombinant (hFc)

Name: NRG1 beta 1 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-02705
Rating: 4.5 (1 reviews)

(Synonyms: SMDF, NRG1-IT2, NRG1 β1, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, Heregulin beta-1, GGF2, GGF, ARIA) Copy Product Info

Synonyms: SMDF, NRG1-IT2, NRG1 β1, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, Heregulin beta-1, GGF2, GGF, ARIA

Catalog No. TMPY-02705 Copy Product Info

NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 54 kDa and the accession number is Q02297-6.

Pack Size	Price	USA Stock	Global Stock
5 µg	$36	7-10 days	7-10 days
10 µg	$55	7-10 days	7-10 days
20 µg	$87	7-10 days	7-10 days
50 µg	$167	7-10 days	7-10 days
100 µg	$319	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human Her4, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 18.7 ng/ml determined by ELISA (QC Test). Immobilized Human Her3, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 17.1 ng/ml determined by ELISA.
Description	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 54 kDa and the accession number is Q02297-6.
Species	Human
Expression System	HEK293 Cells
Tag	N-hFc (IgG1)
Accession Number	Q02297-6
Construction	Ser2-Lys246
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	SMDF, NRG1-IT2, NRG1 β1, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, Heregulin beta-1, GGF2, GGF, ARIA
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

Chemical Properties

Molecular Weight

54 kDa (predicted); 70-80 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.