NRG1 beta 1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02705

NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.

NRG1 beta 1 Protein, Human, Recombinant (hFc)

Catalog No. TMPY-02705

NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.

Pack Size	Price	Availability
5 μg	$36	7-10 days
10 μg	$55	7-10 days
20 μg	$87	7-10 days
50 μg	$167	7-10 days
100 μg	$319	7-10 days

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Product Information

Biological Activity	1. Immobilized Human ERBB3 His at 2 μg/ml (100 μl/well) can bind Human NRG1 Fc , the EC50 of Human NRG1 Fc is 8-40 ng/mL. 2. Immobilized Rhesus ERBB3 His at 2 μg/ml (100 μl/well) can bind Human NRG1 Fc , the EC50 of Human NRG1 Fc is 20-80 ng/mL.
Description	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
Species	Human
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	Q02297-6
Synonyms	SMDF,NRG1-IT2,NRG1 β1,neuregulin 1,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,Heregulin beta-1,GGF2,GGF,ARIA
Construction	A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was fused with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu
Protein Purity	> 85 % as determined by SDS-PAGE
Molecular Weight	55.2 kDa (predicted); 75 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.