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SB-399885 hydrochloride

Name: SB-399885 hydrochloride
Brand: TargetMol
SKU: T12843
Rating: 4.5 (1 reviews)

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Catalog No. T12843Cas No. 402713-81-9

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

SB-399885 hydrochloride

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Catalog No. T12843Cas No. 402713-81-9

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

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Product Introduction

Bioactivity

Description

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

In vivo

SB-399885 hydrochloride, administered at a dose of 10 mg/kg, significantly enhances wakefulness (W) (F(3,15)=3.32, P<0.05) and decreases both slow wave sleep (SWS) and rapid-eye-movement sleep (REMS), as well as reducing the number of REM periods (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively) compared to the control vehicle. Further analysis on 2-hour intervals revealed that this dose increased W (F(3,15)=5.48, P<0.01) and diminished SWS and REMS during the initial 2-hour period (F(3,15)=5.42, P<0.01 and F(3,15)= 4.05, P<0.01, respectively). Additionally, doses of 5 and 10 mg/kg were found to increase light sleep across the first and second 2-hour recording periods (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01; and F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively). The 10 mg/kg dose also notably prolonged REMS latency (F(3,15)=3.60, P<0.01) and decreased the number of REM periods within the first two hours of recording (F(3,15)=3.88, P<0.01).

Chemical Properties

Molecular Weight	482.81
Formula	C₁₈H₂₂Cl₃N₃O₄S
Cas No.	402713-81-9
Smiles	Cl.COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1OC
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (258.9 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0712 mL	10.3560 mL	20.7121 mL	103.5604 mL
5 mM	0.4142 mL	2.0712 mL	4.1424 mL	20.7121 mL
10 mM	0.2071 mL	1.0356 mL	2.0712 mL	10.3560 mL
20 mM	0.1036 mL	0.5178 mL	1.0356 mL	5.1780 mL
50 mM	0.0414 mL	0.2071 mL	0.4142 mL	2.0712 mL
100 mM	0.0207 mL	0.1036 mL	0.2071 mL	1.0356 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc