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Pyrithione

Name: Pyrithione
Brand: TargetMol
SKU: T12593
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12593Cas No. 1121-30-8

Alias 1-hydroxyl-1H-pyridine-2-thione

Pyrithione (1-hydroxyl-1H-pyridine-2-thione) is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity.

Pyrithione

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Purity: 99.55%

Catalog No. T12593Alias 1-hydroxyl-1H-pyridine-2-thioneCas No. 1121-30-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$87	In Stock	In Stock
50 mg	$116	In Stock	In Stock
100 mg	$157	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Pyrithione AI Summary

Pyrithione exhibits a combination of bioactivities across various molecular targets. It shows binding affinity to human ESR1 (Estrogen Receptor Alpha) with an AC50 value of 22,261.8 nM. The compound inhibits human PTGS1 (Prostaglandin-Endoperoxide Synthase 1) with AC50 values of 6,742.3 nM and 12,409.4 nM in different assays. It functions as an agonist at human CHRM1 (Muscarinic Acetylcholine Receptor M1) with an AC50 value of 14,576.1 nM and also acts as an antagonist at the same receptor with an AC50 value of 833.5 nM. Additionally, Pyrithione displays agonist activity at human TBXA2R (Thromboxane A2 Receptor) with an AC50 value of 3,789.1 nM and acts as an antagonist at human ADRA1A (Alpha-1 Adrenergic Receptor) with an AC50 value of 1,528.2 nM. These diverse activities indicate its potential for multifaceted pharmacological effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyrithione (1-hydroxyl-1H-pyridine-2-thione) is a transition metal complex, a zinc ionophore, that causes elevated zinc levels in mammalian cells. Pyrithione has potent bactericidal and antifungal activity.
Synonyms	1-hydroxyl-1H-pyridine-2-thione

Chemical Properties

Molecular Weight	127.16
Formula	C₅H₅NOS
Cas No.	1121-30-8
Smiles	S=C1N(O)C=CC=C1
Relative Density.	1.255 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 135 mg/mL (1061.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (31.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.8641 mL	39.3205 mL	78.6411 mL	393.2054 mL
5 mM	1.5728 mL	7.8641 mL	15.7282 mL	78.6411 mL
10 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
20 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
50 mM	0.1573 mL	0.7864 mL	1.5728 mL	7.8641 mL
100 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc