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CPI-1205

Name: CPI-1205
Brand: TargetMol
SKU: T8510
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8510Cas No. 1621862-70-1

Alias Lirametostat

CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .

CPI-1205

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Purity: 99.86%

Catalog No. T8510Alias LirametostatCas No. 1621862-70-1

CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$85	In Stock	In Stock
2 mg	$123	In Stock	In Stock
5 mg	$223	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$556	In Stock	In Stock
50 mg	$783	-	In Stock
1 mL x 10 mM (in DMSO)	$473	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.86%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
Targets&IC50	EZH2:0.002 μM
In vivo	CPI-1205 is a highly potent (biochemical IC50 = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of EZH2.?This compound demonstrates robust antitumor effects in a Karpas-422 xenograft model when dosed at 160 mg/kg BID.
Synonyms	Lirametostat

Chemical Properties

Molecular Weight	518.57
Formula	C₂₇H₃₃F₃N₄O₃
Cas No.	1621862-70-1
Smiles	[C@H](C)(N1C=2C(C(C(NCC3=C(OC)C=C(C)NC3=O)=O)=C1C)=CC=CC2)C4CCN(CC(F)(F)F)CC4
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (183.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9284 mL	9.6419 mL	19.2838 mL	96.4190 mL
5 mM	0.3857 mL	1.9284 mL	3.8568 mL	19.2838 mL
10 mM	0.1928 mL	0.9642 mL	1.9284 mL	9.6419 mL
20 mM	0.0964 mL	0.4821 mL	0.9642 mL	4.8209 mL
50 mM	0.0386 mL	0.1928 mL	0.3857 mL	1.9284 mL
100 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.9642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc