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AZA1

Name: AZA1
Brand: TargetMol
SKU: T61448
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61448Cas No. 1071098-42-4

Alias Rac1/Cdc42-IN-1

AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.

AZA1

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Purity: 99.75%

Catalog No. T61448Alias Rac1/Cdc42-IN-1Cas No. 1071098-42-4

AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Purity:99.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.
In vitro	AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) impedes the proliferation of human 22Rv1 prostate cancer cells, diminishes phosphorylation of PAK1, AKT, and BAD in EGF-stimulated 22Rv1 cells (2-10 μM; 24 hours), and obstructs Rac1 and Cdc42-dependent cell cycle progression (10 μM; 24 hours). AZA1 also inhibits Rac1 and Cdc42-dependent migration of 22Rv1, DU 145, and PC-3 prostate cancer cells, impacting cell motility and actin reorganization through PAK1/2 phosphorylation suppression.
In vivo	AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) effectively suppresses human 22Rv1 xenograft growth in 5-week-old athymic nu/nu (nude) mice and improves survival, with a significant impact on tumor growth suppression.[1]
Synonyms	Rac1/Cdc42-IN-1

Chemical Properties

Molecular Weight	368.43
Formula	C₂₂H₂₀N₆
Cas No.	1071098-42-4
Smiles	Cc1cc2cc(Nc3ccnc(Nc4ccc5[nH]c(C)cc5c4)n3)ccc2[nH]1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (162.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7142 mL	13.5711 mL	27.1422 mL	135.7110 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	27.1422 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	13.5711 mL
20 mM	0.1357 mL	0.6786 mL	1.3571 mL	6.7855 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7142 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	1.3571 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc