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Epertinib hydrochloride

Name: Epertinib hydrochloride
Brand: TargetMol
SKU: T11213
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11213Cas No. 2071195-74-7

Alias S-22611 hydrochloride

Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.

Epertinib hydrochloride

🥰Excellent

Purity: 99.14%

Catalog No. T11213Alias S-22611 hydrochlorideCas No. 2071195-74-7

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$198	In Stock
10 mg	$328	In Stock
25 mg	$562	In Stock
50 mg	$795	In Stock
100 mg	$1,070	In Stock
500 mg	$2,150	In Stock
1 mL x 10 mM (in DMSO)	$268	In Stock

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Batch Information

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Purity:99.14%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively.
Targets&IC50	HER2:7.15 nM, HER4:2.49 nM, EGFR:1.48 nM
Synonyms	S-22611 hydrochloride

Chemical Properties

Molecular Weight	596.48
Formula	C₃₀H₂₈Cl₂FN₅O₃
Cas No.	2071195-74-7
Smiles	Cl.CC#C\C(=N/OC[C@H]1COCCN1)c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (209.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6765 mL	8.3825 mL	16.7650 mL	83.8251 mL
5 mM	0.3353 mL	1.6765 mL	3.3530 mL	16.7650 mL
10 mM	0.1677 mL	0.8383 mL	1.6765 mL	8.3825 mL
20 mM	0.0838 mL	0.4191 mL	0.8383 mL	4.1913 mL
50 mM	0.0335 mL	0.1677 mL	0.3353 mL	1.6765 mL
100 mM	0.0168 mL	0.0838 mL	0.1677 mL	0.8383 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc