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LP44 hydrochloride (Synonyms: LP-44 hydrochloride, LP44 hydrochloride)

Name: LP44 hydrochloride
Brand: TargetMol
SKU: T22931
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T22931 Copy Product Info

Purity: 98.06%

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LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.

LP44 hydrochloride

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Catalog No. T22931

Synonyms LP-44 hydrochloride, LP44 hydrochloride

Cas No. 824958-12-5

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$33	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.06%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.
In vivo	METHODS: LP44 hydrochloride (10.3, 20.5, 41.0 nM) was intracerebroventricularly administered to CBA/Lac mice, and the vital signs of the mice were observed. RESULTS: LP44 hydrochloride can produce a considerable hypothermic response in mice. [1]
Synonyms	LP-44 hydrochloride, LP44 hydrochloride

Chemical Properties

Molecular Weight	488.13
Formula	C₂₇H₃₈ClN₃OS
Cas No.	824958-12-5
Smiles	Cl.O=C(NC1C=2C=CC=CC2CCC1)CCCCCN3CCN(C=4C=CC=CC4SC)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (163.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0486 mL	10.2432 mL	20.4863 mL	102.4317 mL
5 mM	0.4097 mL	2.0486 mL	4.0973 mL	20.4863 mL
10 mM	0.2049 mL	1.0243 mL	2.0486 mL	10.2432 mL
20 mM	0.1024 mL	0.5122 mL	1.0243 mL	5.1216 mL
50 mM	0.0410 mL	0.2049 mL	0.4097 mL	2.0486 mL
100 mM	0.0205 mL	0.1024 mL	0.2049 mL	1.0243 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc