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LP44 hydrochloride

Name: LP44 hydrochloride
Brand: TargetMol
SKU: T22931
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22931Cas No. 824958-12-5

Alias LP-44 hydrochloride, LP44 hydrochloride

LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.

LP44 hydrochloride

🥰Excellent

Purity: 98.06%

Catalog No. T22931Alias LP-44 hydrochloride, LP44 hydrochlorideCas No. 824958-12-5

Pack Size	Price	Availability	Quantity
1 mg	$33	In Stock

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Purity:98.06%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.
In vivo	METHODS: LP44 hydrochloride (10.3, 20.5, 41.0 nM) was intracerebroventricularly administered to CBA/Lac mice, and the vital signs of the mice were observed. RESULTS: LP44 hydrochloride can produce a considerable hypothermic response in mice. [1]
Synonyms	LP-44 hydrochloride, LP44 hydrochloride

Chemical Properties

Molecular Weight	488.13
Formula	C₂₇H₃₈ClN₃OS
Cas No.	824958-12-5
Smiles	Cl.O=C(NC1C=2C=CC=CC2CCC1)CCCCCN3CCN(C=4C=CC=CC4SC)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (163.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0486 mL	10.2432 mL	20.4863 mL	102.4317 mL
5 mM	0.4097 mL	2.0486 mL	4.0973 mL	20.4863 mL
10 mM	0.2049 mL	1.0243 mL	2.0486 mL	10.2432 mL
20 mM	0.1024 mL	0.5122 mL	1.0243 mL	5.1216 mL
50 mM	0.0410 mL	0.2049 mL	0.4097 mL	2.0486 mL
100 mM	0.0205 mL	0.1024 mL	0.2049 mL	1.0243 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc