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HS-276

Name: HS-276
Brand: TargetMol
SKU: T62209
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62209Cas No. 2767422-72-8

HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).

HS-276

🥰Excellent

Purity: 98.81%

Catalog No. T62209Cas No. 2767422-72-8

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$230	In Stock
25 mg	$453	In Stock
50 mg	$727	In Stock
100 mg	$1,120	In Stock
200 mg	$1,510	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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Purity:98.81%

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COA HNMR LCMS LCMS

Product Introduction

Bioactivity

Description	HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).
Targets&IC50	NUAK:270 nM, CLK2:29 nM, ULK2:63 nM, CaMKK β1:1280 nM, CSNK1G2:810 nM, GCK:33 nM, MAP4K5:125 nM, MLK1:5585 nM, IRAK4:2500 nM, TAK1:8.25 nM, IRAK1:264 nM, TAK1:2.5 nM (Ki)

Chemical Properties

Molecular Weight	419.52
Formula	C₂₄H₂₉N₅O₂
Cas No.	2767422-72-8
Smiles	C(CC)N1C=2C(N=C1NC(=O)C3=CC(C(N)=O)=CC=C3)=CC=C(CN4CCCCC4)C2
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45.0 mg/mL (107.3 mM), when pH is adjusted to 2 with HCl. Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3837 mL	11.9184 mL	23.8368 mL	119.1838 mL
5 mM	0.4767 mL	2.3837 mL	4.7674 mL	23.8368 mL
10 mM	0.2384 mL	1.1918 mL	2.3837 mL	11.9184 mL
20 mM	0.1192 mL	0.5959 mL	1.1918 mL	5.9592 mL
50 mM	0.0477 mL	0.2384 mL	0.4767 mL	2.3837 mL
100 mM	0.0238 mL	0.1192 mL	0.2384 mL	1.1918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc