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HS-276

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Catalog No. T62209Cas No. 2767422-72-8

HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).

HS-276

HS-276

😃Good
Purity: 98.81%
Catalog No. T62209Cas No. 2767422-72-8
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$61In StockIn Stock
5 mg$147In StockIn Stock
10 mg$230In StockIn Stock
25 mg$453In StockIn Stock
50 mg$727In StockIn Stock
100 mg$1,120-In Stock
200 mg$1,510-In Stock
1 mL x 10 mM (in DMSO)$173In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.81%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA).
Targets&IC50
MAP4K5:125 nM, MLK1:5585 nM, CaMKK β1:1280 nM, CSNK1G2:810 nM, TAK1:2.5 nM (Ki), NUAK:270 nM, CLK2:29 nM, GCK:33 nM, TAK1:8.25 nM, IRAK1:264 nM, ULK2:63 nM, IRAK4:2500 nM
Chemical Properties
Molecular Weight419.52
FormulaC24H29N5O2
Cas No.2767422-72-8
SmilesC(CC)N1C=2C(N=C1NC(=O)C3=CC(C(N)=O)=CC=C3)=CC=C(CN4CCCCC4)C2
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (107.27 mM), when pH is adjusted to 2 with HCl. Sonication and heating to 80℃ are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.77 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3837 mL11.9184 mL23.8368 mL119.1838 mL
5 mM0.4767 mL2.3837 mL4.7674 mL23.8368 mL
10 mM0.2384 mL1.1918 mL2.3837 mL11.9184 mL
20 mM0.1192 mL0.5959 mL1.1918 mL5.9592 mL
50 mM0.0477 mL0.2384 mL0.4767 mL2.3837 mL
100 mM0.0238 mL0.1192 mL0.2384 mL1.1918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAK1
Related Tags: buy HS-276 | purchase HS-276 | HS-276 cost | order HS-276 | HS-276 chemical structure | HS-276 formula | HS-276 molecular weight
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