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NLRP3-IN-9

🥰Excellent
Catalog No. T28178Cas No. 88039-46-7
Alias INF-4E, INF4E, INF 4E

NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.

NLRP3-IN-9

NLRP3-IN-9

🥰Excellent
Purity: 99.64%
Catalog No. T28178Alias INF-4E, INF4E, INF 4ECas No. 88039-46-7
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35-In Stock
5 mg$81-In Stock
10 mg$129-In Stock
25 mg$263-In Stock
50 mg$428-In Stock
100 mg$679-In Stock
1 mL x 10 mM (in DMSO)$80-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.64%
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Product Introduction

Bioactivity
Description
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
SynonymsINF-4E, INF4E, INF 4E
Chemical Properties
Molecular Weight240.68
FormulaC12H13ClO3
Cas No.88039-46-7
SmilesCCOC(=O)C(=C)C(O)c1ccccc1Cl
Relative Density.1.222 g/cm3 (Predicted)
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (249.29 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.31 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1549 mL20.7745 mL41.5489 mL207.7447 mL
5 mM0.8310 mL4.1549 mL8.3098 mL41.5489 mL
10 mM0.4155 mL2.0774 mL4.1549 mL20.7745 mL
20 mM0.2077 mL1.0387 mL2.0774 mL10.3872 mL
50 mM0.0831 mL0.4155 mL0.8310 mL4.1549 mL
100 mM0.0415 mL0.2077 mL0.4155 mL2.0774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

THP-1 cellspyroptosisNOD-like Receptor (NLR)NLRP3-IN-9NLRP-3-IN-9NLRP3IN9NLRP3 IN 9NLRP3myocardial injuryInhibitorinhibitinflammasomedysfunctioncaspase-1
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