Anti-TDP2 Polyclonal Antibody is a Rabbit antibody targeting TDP2. Anti-TDP2 Polyclonal Antibody can be used in WB.

IgG

Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit)

Sample: Thymus (Mouse) Lysate at 40 μg
Primary: Anti-ETS1 associated protein II (TMAB-13440) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kD
Observed band size: 39 kD

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human ETS1 associated protein II/EAPII

Human

TDP2

Tyrosyl-DNA phosphodiesterase 2

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.