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(S)-Mapracorat

Name: (S)-Mapracorat
Brand: TargetMol
SKU: T13451
Rating: 4.5 (1 reviews)

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Catalog No. T13451Cas No. 887375-15-7

Alias (S)-ZK-245186, (S)-BOL-303242X

(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.

(S)-Mapracorat

🥰Excellent

Catalog No. T13451Alias (S)-ZK-245186, (S)-BOL-303242XCas No. 887375-15-7

(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.

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Product Introduction

Bioactivity

Description	(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.
In vivo	During the 60-minute observation period, intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a significant wheal and flare reaction. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.
Synonyms	(S)-ZK-245186, (S)-BOL-303242X

Chemical Properties

Molecular Weight	462.48
Formula	C₂₅H₂₆F₄N₂O₂
Cas No.	887375-15-7
Smiles	Cc1ccc2c(NC[C@@](O)(CC(C)(C)c3cc(F)cc4CCOc34)C(F)(F)F)cccc2n1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.6 mg/mL (109.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1623 mL	10.8113 mL	21.6226 mL	108.1128 mL
5 mM	0.4325 mL	2.1623 mL	4.3245 mL	21.6226 mL
10 mM	0.2162 mL	1.0811 mL	2.1623 mL	10.8113 mL
20 mM	0.1081 mL	0.5406 mL	1.0811 mL	5.4056 mL
50 mM	0.0432 mL	0.2162 mL	0.4325 mL	2.1623 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc