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Anti-PACAP38 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human pituitary adenylate cyclase-activating polypeptide 38 isoform with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of ligand-mediated signaling within the GPCR/G Protein pathway to evaluate its functional role in neurovascular regulation during strictly monitored laboratory observation periods and functional cyclic AMP accumulation assays to ensure high experimental sensitivity.

| Description | Anti-PACAP38 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human pituitary adenylate cyclase-activating polypeptide 38 isoform with exceptional binding affinity and selectivity, effectively facilitating the measurable neutralization of ligand-mediated signaling within the GPCR/G Protein pathway to evaluate its functional role in neurovascular regulation during strictly monitored laboratory observation periods and functional cyclic AMP accumulation assays to ensure high experimental sensitivity. |
| Targets&IC50 | PACAP:2.3 pM (Kd) |
| In vitro | In cell-based reporter assays, Anti-PACAP38 Antibody (ALD1910) potently neutralized PACAP38-induced cAMP production with high affinity [1]. |
| In vivo | In rat models of vasodilation, systemic administration of Anti-PACAP38 Antibody (ALD1910) significantly inhibited PACAP38-induced increases in meningeal blood flow [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PACAP38 |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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