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Dicloxacillin Sodium

Name: Dicloxacillin Sodium
Brand: TargetMol
SKU: T6471
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6471Cas No. 343-55-5

Alias Veracillin Sodium, Sodium dicloxacillin, BRL1702 Sodium

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.

Dicloxacillin Sodium

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Catalog No. T6471Alias Veracillin Sodium, Sodium dicloxacillin, BRL1702 SodiumCas No. 343-55-5

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$50	-	In Stock
50 mg	$65	-	In Stock
100 mg	$118	Inquiry	Inquiry
200 mg	$214	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$87	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.
In vitro	Dicloxacillin Sodium is a narrow-spectrum β-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.[1] Like other β-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. Dicloxacillin is insensitive to beta-lactamase (also known as penicillinase) enzymes secreted by many penicillin-resistant bacteria. The presence of the isoxazolyl group on the side-chain of the penicillin nucleus facilitates the β-lactamase resistance, since they are relatively intolerant of side-chain steric hindrance. Thus, it is able to bind to penicillin-binding proteins (PBPs) and inhibit peptidoglycan crosslinking, but is not bound by or inactivated by β-lactamases. [2]
Synonyms	Veracillin Sodium, Sodium dicloxacillin, BRL1702 Sodium

Chemical Properties

Molecular Weight	510.32
Formula	C₁₉H₁₇Cl₂N₃O₅S·H₂O·Na
Cas No.	343-55-5
Smiles	[Na+].Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O)-c1c(Cl)cccc1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 93 mg/mL (182.24 mM), Sonication is recommended.

H2O: 92 mg/mL (180.28 mM), Sonication is recommended.

Ethanol: 21 mg/mL (41.15 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9596 mL	9.7978 mL	19.5955 mL	97.9777 mL
5 mM	0.3919 mL	1.9596 mL	3.9191 mL	19.5955 mL
10 mM	0.1960 mL	0.9798 mL	1.9596 mL	9.7978 mL
20 mM	0.0980 mL	0.4899 mL	0.9798 mL	4.8989 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0392 mL	0.1960 mL	0.3919 mL	1.9596 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc