Shopping Cart

Your shopping cart is currently empty

Bis-PEG4-NHS ester

Name: Bis-PEG4-NHS ester
Brand: TargetMol
SKU: T14639
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Synonyms:

Catalog No. T14639 Copy Product Info

Purity: 99.81%

🥰Excellent

Bis-PEG4-NHS ester is a bis-N-hydroxysuccinimide-activated tetraethylene glycol crosslinker. Bis-PEG4-NHS‘s NHS groups selectively condense with primary amines to form stable amide bonds, thereby covalently crosslinking proteins, peptides, or small molecules. The PEG4 moiety in Bis-PEG4-NHS ester confers good water solubility and flexibility to the conjugate, effectively suppresses nonspecific adsorption, and reduces steric hindrance, thereby supporting site-specific, copper-free click chemistry coupling between antibodies and liposomes. Bis-PEG4-NHS ester can be used for the preparation of homogeneous antibody-drug conjugates (ADCs) and the modular construction of PROTAC bifunctional molecules.

Cas No. 1314378-11-4

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$30	-	In Stock
100 mg	$40	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	488.44
Formula	C₂₀H₂₈N₂O₁₂
Cas No.	1314378-11-4
Smiles	O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 53.34 mg/mL (109.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0473 mL	10.2367 mL	20.4733 mL	102.3667 mL
5 mM	0.4095 mL	2.0473 mL	4.0947 mL	20.4733 mL
10 mM	0.2047 mL	1.0237 mL	2.0473 mL	10.2367 mL
20 mM	0.1024 mL	0.5118 mL	1.0237 mL	5.1183 mL
50 mM	0.0409 mL	0.2047 mL	0.4095 mL	2.0473 mL
100 mM	0.0205 mL	0.1024 mL	0.2047 mL	1.0237 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc