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Anti-PTGS1 Antibody (7Y100)
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Catalog No. TMAH-01014
Alias PTGS 1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1, PHS 1, PGHS-1, PGH synthase 1, EC 1.14.99.1, Cyclooxygenase-1, COX-1, COX1
Anti-PTGS1 Antibody (7Y100) is an antibody targeting PTGS1. Anti-PTGS1 Antibody (7Y100) can be used in ELISA, WB, FCM.
Anti-PTGS1 Antibody (7Y100)
Anti-PTGS1 Antibody (7Y100)
😃Good
Catalog No. TMAH-01014Alias PTGS 1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1, PHS 1, PGHS-1, PGH synthase 1, EC 1.14.99.1, Cyclooxygenase-1, COX-1, COX1
Anti-PTGS1 Antibody (7Y100) is an antibody targeting PTGS1. Anti-PTGS1 Antibody (7Y100) can be used in ELISA, WB, FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB, FCM Reactivity: Human, Mouse |
| Alias | PTGS 1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, Prostaglandin G/H synthase 1, PHS 1, PGHS-1, PGH synthase 1, EC 1.14.99.1, Cyclooxygenase-1, COX-1, COX1 |
| Ig Type | Rabbit IgG |
| Clone | 7Y100 |
| Reactivity | Human, Mouse |
| Verified Activity | 1. Western Blot -Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Mouse liver tissue -All lanes: PTGS1 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 69, 65, 62, 57, 72, 73 kDa -Observed band size: 72 kDa 2. Overlay histogram showing Hela cells stained with TMAH-01014 (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10^6 cells) for 1 h at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | ELISA, WB, FCM |
| Recommended Dose | WB:1:500-1:5000; FCM:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human COX1 |
| Antigen Species | Human |
| Gene ID | 5742 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Immunology, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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