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GNE-207

Name: GNE-207
Brand: TargetMol
SKU: T15399
Rating: 4.5 (1 reviews)

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Catalog No. T15399Cas No. 2158266-58-9

GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).

GNE-207

😃Good

Catalog No. T15399Cas No. 2158266-58-9

Pack Size	Price	Availability
25 mg	$2,120	8-10 weeks
50 mg	$2,780	8-10 weeks
100 mg	$3,700	8-10 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).
Targets&IC50	CBP:1 nM, BRD41:3.1 μM
In vivo	GNE-207 (5?mg/kg) displays moderate clearance in PK. It has an acceptable oral bioavailability.

Chemical Properties

Molecular Weight	510.59
Formula	C₂₉H₃₀N₆O₃
Cas No.	2158266-58-9
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (391.70 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9585 mL	9.7926 mL	19.5852 mL	97.9259 mL
5 mM	0.3917 mL	1.9585 mL	3.9170 mL	19.5852 mL
10 mM	0.1959 mL	0.9793 mL	1.9585 mL	9.7926 mL
20 mM	0.0979 mL	0.4896 mL	0.9793 mL	4.8963 mL
50 mM	0.0392 mL	0.1959 mL	0.3917 mL	1.9585 mL
100 mM	0.0196 mL	0.0979 mL	0.1959 mL	0.9793 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc