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HSP70-IN-1
🥰Excellent
Catalog No. T3487Cas No. 1268273-90-0
HSP70-IN-1 is a heat shock protein (HSP) inhibitor that suppresses the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
HSP70-IN-1
🥰Excellent
Purity: 99.91%
Catalog No. T3487Cas No. 1268273-90-0
HSP70-IN-1 is a heat shock protein (HSP) inhibitor that suppresses the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $653 | In Stock | |
| 50 mg | $892 | In Stock | |
| 100 mg | $1,230 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $243 | In Stock |
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Purity:99.91%
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Product Introduction
Bioactivity
Chemical Properties
| Description | HSP70-IN-1 is a heat shock protein (HSP) inhibitor that suppresses the growth of Kasumi-1 cells with an IC50 of 2.3 μM. |
| Targets&IC50 | HSP:2.3 μM, Caspase-3:1.9 μM (MOLM13 cells), Caspase-7:1.9 μM (MOLM13 cells) |
| In vitro | Heat shock protein 70 (Hsp70) functions as a molecular chaperone crucial for protein homeostasis, cell signaling, and survival, with its overexpression observed in cancer contributing to chemotherapy resistance. HSP70-IN-1 disrupts this by dose-dependently affecting the formation and stability of the Hsp70-HOP-Hsp90 complex, crucial for cancer cell survival, including altering components of this megacomplex and destabilizing the Hsp70-Hsp90 machinery client, Raf-1. It also inhibits the refolding capability of endogenous and transfected Hsp70 for heat-denatured luciferase in cells, and induces apoptosis in cancer cells by modifying the Hsp70-HOP complex formation and stability, leading to their reduced half-life. |
| Molecular Weight | 464.58 |
| Formula | C24H28N6O2S |
| Cas No. | 1268273-90-0 |
| Smiles | CN1CCN(CC1)c1ncc(Sc2cccc(NC(=O)CN)c2)c(OCc2ccccc2)n1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (96.86 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.3 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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