ED 50 < 0.2 μg/ml, measured by a cell proliferation assay of HUVEC cells in the presence of 2.5 ng/ml h-VEGF, corresponding to a specific activity of > 5.0 × 10^3 IU/mg.

CXCL10 Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is P02778.

Human

E. coli

SCYB10,mob-1,IP-10,INP10,IFI10,gIP-10,crg-2,chemokine (C-X-C motif) ligand 10,C7

Val22-Pro98 Expressed with an N-terminal Met

> 95% as determined by SDS-PAGE > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

IP-10/CXCL10 also known as CXCL10, is originally identified as an IFN-γ-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1β, TNF-α, IL-12 and viruses. Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10.