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Galectin

Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding. There have been about 15 galectins discovered in mammals, encoded by the LGALS genes, which are numbered in a consecutive manner. Only galectin-1, -2, -3, -4, -7, -7B, -8, -9, -9B, 9C, -10, -12, -13, -14, and -16 have been identified in humans. Galectin-5 and -6 are found in rodents, whereas galectin-11 and -15 are uniquely found in sheep and goats. Members of the galectin family have also been discovered in other mammals, birds, amphibians, fish, nematodes, sponges, and some fungi. Unlike the majority of lectins they are not membrane bound, but soluble proteins with both intra- and extracellular functions. They have distinct but overlapping distributions[2] but found primarily in the cytosol, nucleus, extracellular matrix or in circulation. Although many galectins must be secreted, they do not have a typical signal peptide required for classical secretion. The mechanism and reason for this non-classical secretion pathway is unknown.

TD139
T51211450824-22-2In house
TD139 is a small molecule inhibitor of inhaled galectin-3 (Gal-3) with potential anti-fibrotic activity, commonly used in the study of idiopathic pulmonary fibrosis.
  • $64
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Selvigaltin
T637511978336-95-6In house
Selvigaltin (GB1211) is a Gal-3 inhibitor with potential anticancer activity. Selvigaltin is used in the study of cirrhosis and cancer.
  • $289
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GB1107
T153721978336-61-6
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
  • $56
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OTX008
T16413286936-40-1
OTX008 (PTX008) is a selective galectin-1 inhibitor.
  • $64
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N-Acetyl-D-galactosamine
T588514215-68-0
N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans.
  • $40
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Thiodigalactoside
T3807451555-87-4
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
  • $34
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G3-C12 acetate(848301-94-0 free base)
T11346L
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
  • $48
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SNAP 398299
T28822903878-06-8In house
SNAP 398299 is a Glycopeptide Receptor Type 3 (Gal3) antagonist with anxiolytic and antidepressant-like effects and is used in the study of mood disorders.
  • $1,520
1-2 weeks
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DB21, Galectin-1 Antagonist
T826051623027-80-4
DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans on cell surfaces. This compound enhances the inhibition of angiogenesis and tumor growth in melanoma, lung adenocarcinoma, and ovarian cancer models [1].
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6Lac[6]Met
T855091132892-04-6
6Lac[6]Met is a galectin-4 inhibitor with an IC50 value of 5 μM [1].
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Galectin-3/galectin-8-IN-1
T79380
Galectin-3 galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) of 4.12 μM for Galectin-3 and 6.04 μM for galectin-8. It effectively impedes the migration of MRC-5 lung fibroblast cells and is utilized in cancer and tissue fibrosis research [1].
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Galectin-8-IN-1
T61014
Galectin-8-IN-1 is a selective ligand for the galectin-8 N-terminal domain (galectin-8N) with a Kd value of 48 μM, demonstrating 15-fold greater selectivity compared to galectin-3 and outperforming other mammalian galectins.
  • $1,520
10-14 weeks
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Galectin-3/galectin-8-IN-2
T79381
Galectin-3 galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, with dissociation constants (Kd) of 12.8 μM and 2.06 μM, respectively. It effectively inhibits MRC-5 lung fibroblast cell migration and serves as a potential research tool for studying cancer and tissue fibrosis [1].
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Dual Galectin-3/EGFR-IN-1
T204936
Dual Galectin-3 EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.
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Galectin-3-IN-6
T2064572604662-64-6
Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.
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10-14 weeks
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G3-C12
T11346848301-94-0
G3-C12 shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
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Galectin-3-IN-1
T624541989627-40-8
Galectin-3-IN-1 (Compound 1) is a potent inhibitor of polyvalent galactose lectin-3 (Gal-3), which is involved in various metabolic processes related to cancer.
  • $1,520
6-8 weeks
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Apoptosis inducer 8
T634852470024-51-0
Apoptosis inducer 8 is a galectin-1 (gal-1)-mediated apoptosis inducer and a PET imaging agent that significantly reduces gal-1 protein levels and can be used in major lung cancer studies worldwide.
  • $1,520
6-8 weeks
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Galectin-3-IN-2
T64040
Galectin-3-IN-2 is a potent inhibitor of polyvalent galactose lectin-3, with an IC50 value of 8.3 μM for Gal-3. Galectin-3 is involved in many metabolic processes associated with cancer.
  • $1,520
10-14 weeks
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Galectin-8-IN-2
T864901044566-24-6
Galectin-8-IN-2 (Compound 10) acts as an inhibitor of galectin-8N [1].
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3-6 months
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Galectin-3-IN-4
T864872496515-38-7
Galectin-3-IN-4 (compound 5), a carboxamide analog, effectively and selectively inhibits both human and mouse galectin-3. This compound demonstrates notable potency with IC50 values of 21 nM for hGal-3 and 167 nM for mGal-3. It is also orally bioavailable. For other galectins, Galectin-3-IN-4 shows IC50 values of 1580 nM for hGal-1 and 2750 nM for hGal-9, respectively [1].
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10-14 weeks
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GB1490
T864942172866-22-5
GB1490 is an orally administered galectin inhibitor, demonstrating Kd values of 0.4 μM for galectin-1 and 2.7 μM for galectin-3 [1].
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10-14 weeks
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Galectin-8N-IN-2
T88970
Galectin-8N-IN-2 (compound 2) is an effective selective inhibitor of Galectin-8N, with a Ki value of 74 μM.
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Galectin-3-IN-5
T89031
Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), exhibiting an IC50 value of 9.2 nM against hGal-3.
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3-6 months
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